00:01
The protein's function can be disrupted by following factors.
00:07
So proteins function is decided by the tertiary structure of the protein.
00:25
So the primary structure of the protein is amino acid sequence.
00:30
So each amino acid has different side chains.
00:33
So the side chain will have interaction.
00:35
So you can see that a lot of time protein were folded into a specific structure because the interaction between the side chain, they form unique bonds.
00:46
For example, this red one here is hydrogen bond.
00:52
And in some other cases, you will have ionic bond.
01:02
And sometimes you'll have hydrophobic interaction.
01:14
So all these side chains cause the bonds to form between the amino acids.
01:21
So protein will be filled into certain shape.
01:25
Our group side chain form unique bonds to fold a protein into a unique shape.
01:55
And this shape, we always call it confirmation.
02:02
So basically, the bonds between the side group of amino acid decide the function of the protein.
02:11
By folding into its unique confirmation.
02:14
Now, if we look at the function, the factors that affect its function, anything that disrupt the tertiary structure of the protein can affect the function.
02:30
And i want to list the factors that would affect protein, folding.
02:45
So you can have dna mutation.
02:52
The dna mutation is very likely to cause a different codon in mrn.
03:02
Different codon will give you a different amino acid.
03:12
And obviously due to a different amino acid, it can cause the bonds to be changed.
03:19
The interaction between the polypeptide will be changed if you change a certain amino acid.
03:27
So this will change folding by disrupting certain bonds...