Which of the following is not true regarding folding of a...

Which of the following is NOT TRUE regarding folding of a globular protein Group of answer choices An increase in the number of H-bonds for each peptide bond relative to the unfolded state drives folding The primary sequence of the protein confers the structure of the folded state In some cases a chaperone protein is required to aid in folding Folding is hierarchical and local secondary structures form first Folding is driven by burial of hydrophobic residues (releasing ordered water), Van der Waals interactions and ionic interactions (which are stronger in a hydrophobic environment)

Transcript

00:01 Hello students, in this question there are four statements.

00:03 We need to identify whether the given statements are the true statements or false statements.

00:07 So the first statement states that weak individual interactions allow small conformational changes in the protein folding.

00:14 And the second statement states that during the protein folding, polypeptor chains inside the cell always needs the help of a molecular chaperon.

00:21 And the third statement states that the molecule could condense around a hydrophobic core forming a tertiary structure.

00:28 And the last statement states that the entropy of a protein is increased during its folding.

00:34 So to answer all these questions, we need to learn or know about a concept known as protein folding.

00:39 So now we need to learn about protein folding.

00:47 So what do you mean by protein folding? so it is a type of physical process by which the protein chain.

01:05 Is translated to its native three -dimensional structure.

01:27 So in simple terms, after the synthesis of polypeptide chain, the same polypeptide chain should undergo a conformational changes to attain its functional status.

01:37 So such conformational changes from polypeptide chain to a functional protein is known as protein folding.

01:44 Now let us study about structure of a protein, where the structure of a protein is divided into four stages or the levels of organization, where the first level of organization is known as the primary structure, where in the primary structure, linear sequence of amino acids takes place.

02:34 And in the second level of organization, which is the secondary structure.

02:47 So where in the secondary structure, there is a interaction between the hydrogen bonding molecules, which form two sub -levels known as alpha -lix and beta plated sheet...

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