Which of the following is true about Chronic Myellogenous Leukemia (CML)? The main drug for treating CMIL, Gleevec, is an inhibitor of Bor-Abl because it competes with GTP for binding It is caused by a translocation between chromosome 9 and 13.O The chromosome abnormality in CMIL generates a fusion gene that encodes a hyperactive phosphatase None of the above.
Added by William M.
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The primary drug is Gleevec (imatinib), which is indeed an inhibitor of the BCR-ABL fusion protein, not Bor-Abl. Gleevec competes with ATP for binding to the active site of the BCR-ABL tyrosine kinase. Show more…
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Indicate whether each of the following statements is true or false about Chronic Myelogenous Leukemia (CML)? It is caused by a translocation between chromosome 9 and 22. The main drug for treating CML, Gleevec, is an analog of GTP. The chromosome abnormality in CML generates a Bcr-Abl fusion gene. In CML, a super active protein kinase promotes cell proliferation.
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Which of the following is true regarding the cause of Chronic myelogenous leukemia? (Philadelphia chromosome) The BCR/ABL fusion gene that results encodes for a protein with weak tyrosine kinase activity. It is the result of a reciprocal translocation between the long arms of chromosomes 22 and 9. Chromosomal inversion that brings together the NTRK1 gene and TPM3 gene. A cytogenetic change results in the relocation of the ABL oncogene from chromosome 9 to chromosome 22.
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