Which of the following is true regarding the nuclear localization sequence? It is recognized and bound by nuclear import receptors that direct the cargo protein through the nuclear pore into the nucleus. It interacts with a hydrophobic pocket in the nuclear pore complex to enable the entry of the cargo protein into the nucleus. It prevents the cargo protein from diffusing out of the nucleus via nuclear pores. It is cleaved once the cargo protein enters the nucleus.
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Choose all that apply. The NLS (Nuclear Localization Signal/Sequence) is recognized by a soluble nuclear import receptor protein in the cytoplasm and taken to the nuclear pore complexes, for entry into the nucleus. is a post-translational modification is a GFP tag on the protein being imported into the nucleus. is a short stretch of amino acyl residues in the protein destined to the nucleus. has a consensus basic amino acid residue sequence, KKKRK.
Shaiju T.
What is the role of the nuclear localization sequence in a protein? It aids in protein unfolding so that the protein can thread through nuclear pores. It is bound by cytoplasmic proteins that ferry the protein into the nucleus. It is a hydrophobic sequence that enables the protein to enter the nuclear membranes. It prevents the protein from diffusing out of the nucleus through nuclear pores.
Madhur L.
Which of the following statements about transport of proteins into the nucleus is FALSE? Proteins destined for the nucleus contain a nuclear localization signal. Nuclear import receptors recognize the nuclear localization signal on the protein and interact with the fibrils moving the protein across the nuclear membrane. Transport of proteins into the nucleus requires energy in the form of GTP. Transport of proteins into the nucleus requires SRP and the SRP receptor.
Maitreya E.
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