Which of the following is used in blood banks as anticoagulants :- (A) Hirudin (B) Oxalate (c) Heparin (D) Urate
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- Anticoagulants are substances that prevent blood from clotting. In blood banks, they are essential to preserve blood in a liquid state for storage and transfusion. Show more…
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Heparin, a highly negatively charged glycosaminoglycan, is used clinically as an anticoagulant. It acts by binding several plasma proteins, including antithrombin III, an inhibitor of blood clotting. The 1: 1 binding of heparin to antithrombin III seems to cause a conformational change in the protein that greatly increases its ability to inhibit clotting. What amino acid residues of antithrombin III are likely to interact with heparin?
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