Which of the following processes generally requires protein...

Which of the following processes generally requires protein phosphorylation? activation of receptor tyrosine kinases activation of G protein-coupled receptors activation ligand-gated ion channels activation of steroid hormone receptors Which of the following processes generally requires protein phosphorylation? D activation of receptor tyrosine kinases O activation of Gprotein-coupled receptors O activation ligand-gated ion channels O activation of steroid hormone receptors

Transcript

00:01 Okay, i want to answer this question, let's talk about interaction between a ligand and a receptor.

00:05 If this is your cell membrane, you're going to have some molecules that are ligands, okay, that are not going to be able to cross a cell membrane.

00:16 It means they are not allowed to enter the cell membrane because maybe they are too big or they are heavily charged or they are not lipid volume.

00:23 Okay? so, in order, if this molecule is bringing a message for this cell, then this cell is going to make something in order to receive.

00:32 The message from this molecule.

00:34 So as this cell or this molecule cannot enter the cell, then this cell is going to build receptors on the surface of the cell in order to allow the interaction between this ligand and this receptor and practically receive the message in this way.

00:49 Okay, so this question says, activation of which of the following molecule generally requires protein post -forrelation.

00:57 Option g says g protein couple receptors.

01:02 And this is for because in a g protein -capric receptor this is going to be your cell membrane and this is going to be your g -prote like this.

01:09 And here i'm going to have the g -prote, okay, that has three subjunits.

01:14 Once a ligand comes, this alpha subjunct here is going to remove the gdp and it is going to bind gtp.

01:21 But there is no phosphorylation here, okay? so this is not the answer.

01:24 Practically, you don't acquire for phosphorylation here in order to start or to activate this receptor.

01:30 The next option says steroid hormone receptor.

01:32 And steroid hormone receptors are receptors for sterile hormones, and steroid hormones are made of lipids.

01:40 So as this membrane is made of lipics also, then it means that steroid hormones are going to be able to cross a cell membrane like this directly.

01:48 Okay, so it means that the receptors for steroid hormones are going to be found inside of a cell.

01:56 And once this steroid hormone binds to the receptor, this receptor is going to act as a transcription factor and is going to go directly to that no one...

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