Which of the following statements describes integral membrane proteins? Option A they completely span the lipid bilayer Option B they are easily removed from membranes by changes in pH or high salt Option C they tend to be water soluble Option D their association with the membrane is through an attached fatty acyl or prenyl group
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Step 1: Recall that integral membrane proteins span the lipid bilayer and have hydrophobic regions that anchor them within the membrane. Show more…
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When red blood cells are treated extensively with protease, most membrane proteins are broken down into small peptides. However, some proteins are very resistant to this treatment. If cleavage by protease is the only type of reaction that occurs in this treatment, how is this explained? A. They are peripheral membrane proteins. B. They are integral membrane proteins. C. They are lipid-anchored membrane proteins. D. They contain at least 2 disulfide bonds. Determination of the tertiary structure of a membrane protein finds that the outer surface is composed primarily of hydrophobic residues. Which conclusion is most likely from this observation? A. It is a lipid-anchored membrane protein. B. It is an integral membrane protein. C. The protein must be involved in passive transport. D. The protein can undergo transverse diffusion. Sequence analysis of a membrane protein shows four 20-amino acid long stretches of residues that are predominantly hydrophobic. Between each of these stretches of hydrophobic residues, a stretch of predominantly hydrophilic residues is found. From this observation, one can reasonably postulate that: A. This is a peripheral membrane protein which interacts with the membrane via hydrophobic interactions. B. This protein has 4 alpha helical segments that span the membrane. C. This protein can be removed from the membrane by dramatically increasing the salt concentration. D. This is a 4 stranded beta barrel which spans the membrane. E. This is a glycoprotein. Phospholipids can move from one leaflet (layer) to the other in a cell membrane bilayer by A. Increased diffusion. B. Flippases and floppases. C. Lateral diffusion. D. Biosynthesis. If the concentration of a solute is the same both inside and outside the cell, what might you expect with regard to its transport by a membrane protein? A. The solute must be phosphorylated with a phosphate group from ATP before further transport can occur. B. The transport protein has been saturated. C. Movement of the solute across the membrane could occur and cause accumulation on one side of the membrane by an active transport protein. D. Since there is no concentration gradient, no transport either in or out of the cell is possible. Secondary active transport involves the conversion of ATP to ADP. True False Facilitated diffusion (passive transport) through a biological membrane is A. Driven by a concentration gradient. B. Generally irreversible. C. Endergonic. D. Driven by the ATP to ADP conversion. Consider this pathway: epinephrine --> receptor --> G-protein---> Adenyl Cyclase---> cAMP --> protein kinase --> transcription factors. Identify the effector. A. cAMP B. G protein-coupled receptor C. Epinephrine D. Adenyl cyclase Diffusion of membrane proteins was demonstrated by fusing human cells and mouse cells that had membrane proteins labeled with ________ of different colors. A. Stained lipids B. Fluorescent dyes C. Radioactivity D. EPR detectable spin labels Which statement is not true about G proteins? A. They are integral membrane proteins. B. They are slowly inactivated by their own GTPase activity. C. They are multisubunit proteins consisting of α, β, and γ subunits. D. They act as transducers for hormones.
Sri K.
61. What statement about "peripheral" membrane proteins is INCORRECT? A) They are membrane proteins that interact with the polar head groups of the membrane lipids. B) They are membrane proteins that bind to the surfaces of integral proteins. C) They are membrane proteins that are anchored to the membrane by a covalently attached lipid molecule. D) Polar interactions of peripheral protein and polar head groups of the membrane lipids can be disrupted by adding salts or by changing the pH. E) They are membrane proteins that traverse the lipid bilayer.
Lainey R.
Which one of the following statements are true? A) Transverse movement of membrane proteins and lipids cannot occur across the lipid bilayer spontaneously (without using external energy) because it is energetically unfavorable. B) Lateral movement of membrane proteins and lipids cannot occur through the lipid bilayer spontaneously (without using external energy). C) Lateral movement of membrane proteins and lipids occur readily through the lipid bilayer because hydrophobic parts of these molecules easily mix with the lipid bilayer. D) Lateral movement of membrane proteins and lipids occur readily across the lipid bilayer because this movement is thermodynamically unfavorable.
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