Which of the following statements is not true about the generation of diversity in antibodies? The junction for either VJ or VDJ splicing in combinatorial joining can occur between different nucleotides and thus generate different codons in the spliced gene. During somatic mutation, repair of the base pair mismatch is error-free, allowing no further sequence diversity. Combinatorial joining is only one of three mechanisms by which antibody diversity is generated. The V regions of germ-line DNA are susceptible to a high rate of somatic mutation during B-cell development in response to an antigen challenge.
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The junction for VJ or VDJ splicing can occur between different nucleotides, leading to different codons in the spliced gene, which contributes to antibody diversity. - Show more…
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Select the correct statement concerning generation of antibody diversity. Group of answer choices Heavy chain isotype switching produces immunoglobulins with identical C regions but different antigen specificities Sequential switching to different isotypes and subclasses in both directions of the gene can occur during an immune response Antigen-binding sequences are further diversified and can acquire higher affinity following antigen exposure by somatic hypermutation and affinity maturation All our B cell genomes are already rearranged when we are born During recombination, DNA loops out and circular DNA containing intervening sequences is integrated on many human chromosomes
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Which of the following statements about antibody diversity in the immune system is FALSE? Exposing the immune system to too many vaccines overloads its capacity to recognize new antigens. A regulated alternative splice enables a cell to produce secreted and surface-bound forms of the same antibody protein. A site-specific recombinase rearranges genomic DNA in B cells to make antibodies that recognize different antigens. The number of antibody genes in an embryonic human genome is much smaller than the number of antigens that a person is likely to encounter. Antibody gene expression is increased when a series of DNA rearrangements brings an enhancer in an intron closer to an upstream promoter.
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