00:01
Alright, so here we want to choose the things that would increase the proportion of things that proceed by sn2 rather than sn1.
00:10
So number one is use a less reactive nucleophile.
00:18
So when we have a less reactive nucleophile, it's not going to be as good as attacking.
00:24
And so this typically goes through the sn1 reaction because now when a positive carbocadion has formed, it's easier for that weak nucleophile.
00:33
To attack.
00:35
So a less reactive nucleophile will actually promote sn1, so we're not going to select number one.
00:41
Okay, choice two is use a more highly substituted alkyol halide.
00:45
The intermediate for sn1 is a carbocadion, whereas the intermediate for s &2 is a transition state between the two things, one, the leaving group and the thing attaching.
00:57
So if we have a highly substituted alkyo halide, it's going to be difficult for both the thing leaving and the thing attaching to be attached at the same time.
01:08
There will be a lot of bulky steric hindrids there...