Which of these statements about a B cell undergoing somatic hypermutation is true? Group of answer choices It does not need T cell help from T follicular helper cells. It is found in efferent lymphatic vessels. It accumulates mutations in the immunoglobulin variable region. It can no longer differentiate into a memory plasma cell..
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Which of the following is described as the intermediate form of B cells where they secrete antibody but retain substantial surface immunoglobulin and MHC class II molecules and so can continue to take up and present antigen to T cells? plasmablasts memory cells plasma cells erythrocytes Question 11 0.2 pts The germinal center is a region within the secondary B cell follicle where sustained B cell proliferation and differentiation take place. The processes of B cell proliferation and differentiation, including affinity maturation and class switching, require periodic interactions of the germinal center B cells with CD4 TFH cells. These periodic interactions between the B cells and TFH cells can occur: When B cells cycle between the dark zone and the light zone of the germinal center When B cells migrate and form a primary focus of antibody-secreting plasmablasts in the medullary cords of the lymph node When B cells leave the germinal center and migrate through the T-cell zone on their way to the blood When B cells migrate to the border between the T-cell zone and the B-cell zone of the lymph node When B cells up-regulate CXCR4 and migrate into the dark zone of the germinal center
Adi S.
21) Each mature B cell expresses a receptor with a singular specificity for antigen. The binding specificity is generated by a) Alternative splicing b) Somatic recombination of variable region c) Somatic hypermutation of constant region d) Isotype switching e) Clonal selection 22) Which of the following statements regarding the process of differential/alternative splicing of primary RNA transcripts encoding immunoglobulins is correct? a) It involves rearrangement of genomic DNA sequences. b) It is the mechanism necessary for the ability to transcribe the heavy and light chain genes. c) It occurs when a B cell differentiates into a plasma cell d) It permits co-expression of IgD and IgM in mature naïve B lymphocytes e) All of the above 23) In hyper-IgM syndrome, patients can only make low affinity IgM antibodies. This results from a genetic defect in genes which does not allow for which process to occur? a) Somatic recombination of variable region of immunoglobulin gene b) Transcription of immunoglobulin genes c) Isotype switching d) Migration to secondary lymphoid tissues e) Translation of RNA transcripts 24) IgD and Ig M are expressed by a) Hematopoietic stem cells b) Pre-B cells c) Mature naïve B cells d) Plasma cells e) Memory B cells 25) During a secondary immune response, a) There is no lag phase b) Immunoglobulins appear in the circulation faster than the primary response c) Higher titer of antibody is produced d) Affinity of the antibodies is higher than during early stages of primary response e) All of the above
Which statement is NOT correct regarding B-cell development: (choose one) 1) B cells complete maturation in the spleen. 2) B cells are mostly developed but still immature when they leave the bone marrow. 3) The mIgD BCR at the immature B cell stage is replaced by mIgM BCR at the transitional stages in the spleen. 4) Self-reactive B cells may be eliminated through apoptosis.
Shveta P.
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