Which one(s) of the following statement(s) correctly describes/describes factors In renal excretion? Group of answer choices Renal tubular reabsorption rate will be influenced by the rate of renal tubular urine flow. The higher the fraction of free drug, the slower the excretion since the plasma protein-bound form of the drug is eliminated preferentially. The glomerular filtration rate is usually in an important factor in renal excretion. All of the above
Added by Robert M.
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" - This is true because an increased urine flow rate can reduce the time available for reabsorption, thus decreasing reabsorption and increasing excretion. Show more…
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Which one of the following factors best explains an increase in the glomerular filtration rate (GFR)? a) Increased arterial plasma osmotic pressure b) Increased hydrostatic pressure in Bowman's capsule c) Increased glomerular capillary hydrostatic pressure d) Decreased net filtration pressure e) Vasoconstriction of the afferent arteriole Measurements taken after an intravenous injection of inulin indicate that the substance appears to be distributed throughout 30% to 35% of the total body water (TBW). This finding suggests that inulin most likely is a) excluded from the interstitial fluid b) distributed uniformly throughout the total body water volume c) restricted to the plasma volume d) neither excreted nor metabolized by the body e) not freely diffusible across plasma membranes. At plasma concentrations of glucose higher than those associated with the transport maximum (300 mg/dl), which of the following statements is correct? a) The clearance of glucose is zero b) The excretion rate of glucose equals the filtered load of glucose c) The reabsorption rate of glucose equals the filtered load of glucose d) The excretion rate of glucose increases with increasing plasma glucose concentrations. The reabsorption of glucose from the renal tubular lumen into the cells a) depends on the presence of Na+ in the filtrate b) occurs against an electrical gradient c) is a primary active transport process d) is inhibited by the simultaneous transport of para-aminohippuric acid (PAH) e) occurs mainly in the distal tubule. The ascending loop of Henle a) is located for the most part in the renal medulla b) transports Na+ and Cl- to the interstitial tissue space c) BOTH a and b d) NEITHER a nor b. Which of the following statements correctly describes glucose reabsorption by the kidney? a) Secondary active cotransport at the luminal membrane b) Below the renal threshold, the filtered load, and the reabsorption rate are different c) Glucose is actively transported across the basolateral membrane d) Renal glucose transport is Na+-independent e) Renal glucose transport is an electroneutral process.
Adi S.
Renal clearance of the drug CLR = GFR x funbound + Tubular secretion - Tubular reabsorption fu is the unbound fraction of drug Glomerular filtration rate is measured using endogenous creatinine: GFR ≈ creatinine clearance = 100 - 150 ml/min 1/ CLR > GFR x funbound : filtration + Tubular secretion 2/ CLR < GFR x funbound : filtration - Tubular reabsorption 3/ CLR ≈ GFR x funbound : filtration
Madhur L.
Renal physiology (a) The clearance rate of penicillin exceeds the clearance rate of inulin because penicillin is actively transported from the glomerular capillaries into Bowman’s capsule. (b) Angiotensin II is a hormone that increases the synthesis of vasopressin in posterior pituitary cells. (c) Renin is an enzyme that is secreted by granular cells in response to a decline in blood pressure. (d) Both (a) and (b) are correct and (c) is incorrect (e) Statements (a), (b) and (c) are all correct
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