Which receptor must be activated and signal for commitment to the T-cell lineage(s)? Notch GATA-1 IL-17 Artemis
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Step 1: The Notch receptor is essential for T-cell development. Show more…
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Which of the following is true regarding the lineage decisions during T cell development? A. Notch ligands produced by DCs lead to the commitment of ETPs to the T cell fate B. Notch ligands expressed by thymic epithelial cells lead to the commitment of ETPs to the T cell fate C. Wnt ligands expressed by thymic epithelial cells lead to the commitment of ETPs to the T cell fate D. B and C E. None of the above
Md.Daniyal A.
Thymocytes that arrive in the thymus begin to express the pre-T receptor, which allows them to interact with thymic stromal cells and begin to rearrange their TCR genes. CD4 or CD8 CD34 pre-T receptor IL-7 A thymocyte that has successfully rearranged its genes to make gamma and delta chains ___________. begins to bind to MHC I or II proteins continues to develop in the thymus becomes apoptotic leaves the thymus and begins to recirculate, looking for antigens to bind to. During positive selection of T cells, binding of the TCR to MHC-peptides presented by thymic epithelial cells _________________. is required for survival is the signal for apoptosis triggers production of both CD4 and CD8 so thymocytes are double-positive determines whether the T cell will be a cytotoxic T cell or a helper cell
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