Which statements about the modification of chromatin...

Which statements about the modification of chromatin structure in eukaryotes are true? Select all that apply. A. Deacetylation of histone tails in chromatin loosens the association between nucleosomes and DNA. B. Acetylation of histone tails in chromatin allows access to DNA for transcription. C. DNA is not transcribed when chromatin is packaged tightly in a condensed form. D. Methylation of histone tails in chromatin can promote condensation of the chromatin. E. Acetylation of histone tails is a reversible process. F. Some forms of chromatin modification can be passed on to future generations of cells.

Transcript

00:01 Okay, so in this question we have different statements regarding modifications in the chromatin structure.

00:07 So, first statement that is correct in this is the regarding the acetylation of the histone tails.

00:16 So, we know that there are histone tails present in the chromatin and what they do? so, they would basically allow us to have access to the dna for the process of transcription.

00:35 So, this is one statement that is true and it is the statement b.

00:40 So, if we talk more about the acetylation, so acetylation of histone tails would have a positive charge.

00:51 So, they would neutralize their neutralization of positive charge due to acetylation and due to this there would be reduction in the interaction with dna.

01:08 So, we have reduction of interaction with dna and this would make the chromatin structure overall more open and due to this openness it would be more accessible for all the different transcription factors and enzyme to approach.

01:25 So, next statement that is true is a statement c which says that dna is not transcribed.

01:32 So, it is not transcribed when the chromatin is a tightly packed because in this condition the different transcription factors and enzyme would not be able to reach in the dna.

01:48 So, we have this case of heterochromatin and here it would basically inhibit the process of a gene transcription.

02:00 So, gene transcription is inhibited in the heterochromatin structure because there would be overall less accessibility.

02:10 So, accessibility is very low, very low in case of tightly packed, tightly packed dna and here the transcription machinery would not be able to easily approach the dna at all.

02:29 So, therefore it is not transcribed.

02:32 So, next statement which is true is the statement d which is about methylation...

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