00:01
So, strengths and weaknesses of whole exome sequencing.
00:10
All right, so let's start with the strengths.
00:15
It's very efficient.
00:20
So, west focuses on protein coding regions, which represent 1 -2 % of the genome, but they're responsible for the majority of known disease -causing mutations.
00:30
This is going to make it cost -effective to compare to whole genome sequencing, so more efficient.
00:36
It's going to be relevant, because mutations in exons are more likely to directly impact protein function and thus contribute to observable phenotypes, like disease, making this approach a more powerful tool to identify any causative genetic variants.
01:04
And then the last strength is that it's well -established.
01:15
So, west is a well -established technique.
01:19
It's widely used.
01:20
It has very clear, robust protocols and a large amount of evidence and existing research data, clinical data, to support it.
01:32
So, those are the strengths.
01:34
Let's look at the weaknesses.
01:39
So, i also have three weaknesses.
01:41
The first one is going to be limited coverage...