Why would changes in the genes for transcription factors be expected to generate major phenotypic differences? They are very highly expressed genes. They can affect the expression of large numbers of other genes. They can affect the expression of relatively few other genes. Their gene products normally denature more rapidly than other gene products. Their gene products are remarkably stable.
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This means that any alterations in these genes can have a significant impact on the regulation of gene expression in the cell. Show more…
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Why don't some mutations to a DNA sequence have a significant effect on phenotypic expression? (2 points) A mutation may cause a change that codes for the same amino acid. The transcription machinery can skip over the mutation in some cases. Proteins are replicated so often that some mutations are not important. A mutation may affect a DNA sequence but not affect resulting mRNA.
Adi S.
Transcription: Review question: We will start this section by looking at how transcription occurs, but it is also important to understand why it occurs: * What is the final product of transcription? * What is the purpose of making that final product? 1. The human genome contains ~25,000 different genes. What are some of the issues that would be relevant for changing the expression of one of those genes? 2. Transcription factors are what dictate which genes will be expressed. How can a protein locate and bind to one specific spot in your DNA? (Hint: What makes that spot different from all the other locations in the DNA? How could a protein bind to that spot but no others?) 3. Every cell in your body has the same DNA genome. How can you express a gene in one of your cells but not in another one of your cells?
Jenny W.
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