You are called upon to visit the ailing Col. Lemon. Before you see him, you speak to three witnesses who were with him when he fell ill... - Ms. Magenta: "Col. Lemon has been hot-blooded for as long as I have known him. But I noticed that he couldn't seem to keep warm. He kept complaining about being cold." - Mr. Olive: "Just between you and me, I've noticed that the old chap has put on quite a bit of weight lately." - Prof. Purple: "The colonel and I used to go on major expeditions together. Now he just doesn't seem to have the energy for much of anything." What are your initial thoughts about the witness statements? Does one hormone come to mind that may be the cause?
Added by Jes-S G.
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Step 1: Based on the witness statements, we can see that Colonel Lemon is feeling cold, has gained weight, and has lower energy levels. Show more…
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The Bloated Ms. Blanc Your next call is to the home of Ms. Blanc. As before, you have three witnesses to interview. Witness statements: Ms. Magenta: "Between you and me, she has really let herself go. She has fat deposits in all of these strange places, like around her face and trunk, and a weird hump on her back. If you ask me, some exercise may do her some good!" Col. Lemon: "Not that I want to talk about such things, but she has seemed bloated, a bit swollen, lately. She told me that even her blood pressure has gone up!" Mrs. Feather: "The poor dear. She has been sick so much lately with all kinds of infections. Personally, I think her immune system needs boosting. But my herbal teas don't seem to help." What are your initial thoughts based upon the witnesses' statements? Does one hormone come to mind that could produce these effects? Your next stop is to speak with Ms. Blanc. During the interview, you notice a bottle of pills on her nightstand. You log the pills as evidence and send them off to the lab for analysis. The lab report shows the pills to be the medication prednisone, which you know to be a glucocorticoid similar to the hormone cortisol taken to reduce inflammation. Is this finding significant? Why or why not? Based on the witness statements and the laboratory analysis, what is your final diagnosis? Explain.
Maitreya E.
At 10 am, you wander into the Billiard Room and find Miss Scarlett, who has met her untimely end with The Candlestick. Stressed though you are by this terrible sight, you realize that you must catch the murderer. Fortunately, you have the presence of mind to measure the temperature of the body: 82.6 degrees Fahrenheit. Then, you realize that you should round up all possible suspects... Colonel Mustard has an alibi from 3 pm – 5 pm and 9:30 pm – 5 am, Mr. Green has an alibi from 4 pm – 9 pm, and Mrs. Peacock has an alibi from 8 pm – 1 am. At 11 am, you measure the temperature of the body again (81.7 degrees Fahrenheit) and the temperature at which the Billiard Room is kept (72 degrees Fahrenheit). Which suspect should you detain for questioning?
Amy A.
The human body must maintain its core temperature inside a rather narrow range around $37^{\circ} \mathrm{C}$ Metabolic processes, notably muscular exertion, convert chemical energy into internal energy deep in the interior. From the interior, energy must flow out to the skin or lungs to be expelled to the environment. During moderate exercise, an $80-\mathrm{kg}$ man can metabolize food energy at the rate $300 \mathrm{kcal} / \mathrm{h},$ do $60 \mathrm{kcal} / \mathrm{h}$ of mechanical work, and put out the remaining $240 \mathrm{kcal} / \mathrm{h}$ of energy by heat. Most of the energy is carried from the body interior out to the skin by forced convection (as a plumber would say), whereby blood is warmed in the interior and then cooled at the skin, which is a few degrees cooler than the body core. Without blood flow, living tissue is a good thermal insulator, with thermal conductivity about $0.210 \mathrm{W} / \mathrm{m} \cdot^{\circ} \mathrm{C}$. Show that blood flow is essential to cool the man's body by calculating the rate of energy conduction in kcal/h through the tissue layer under his skin. Assume that its area is $1.40 \mathrm{m}^{2},$ its thickness is $2.50 \mathrm{cm},$ and it is maintained at $37.0^{\circ} \mathrm{C}$ on one side and at $34.0^{\circ} \mathrm{C}$ on the other side.
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