Question

You are employed at a biotech company, working on a new drug, named ZZZ, which is a sleep aide. Your boss wants to know how this compound moves into red blood cells, and what its concentration will be in red blood cells. He has provided you with plenty of samples of drug ZZZ, and you have the means to measure its concentration (mmol l-1) inside and outside red blood cells, as well as the concentration of any metabolites of drug ZZZ (in case the body can turn ZZZ into other things). He has now asked you for a protocol, and predictions of how the data will come out depending on how ZZZ crosses the red blood cell membrane. Drug ZZZ may move into red blood cells by simple diffusion through the lipid bilayer. If so, graph the concentration of drug ZZZ inside and outside of the red blood cell vs. time. Assume that when you drop the red blood cells into the bathing solution that they initially contain zero ZZZ. (2 pts). After five minutes, the concentration of drug ZZZ in the red blood cells is 7 mmoles l-1. What is the rate of entry of drug ZZZ into the red blood cells in units of moles min-1 red blood cell-1 during the first five minutes after placing the red blood cells into the bathing solution. Assume that each red blood cell occupies about 1 x 10-13 liters. Show your work. (2 pts). Graph rate of entry of ZZZ into the red blood cells (moles min-1 red blood cell-1) vs. the concentration of ZZZ in the bathing solution, assuming ZZZ enters the red blood cells by diffusion. The point is to know the correct shape of the graph. (1 pt). Drug ZZZ may enter red blood cells by protein-facilitated diffusion. Graph the rate of entry of drug ZZZ into the red blood cells vs. the concentration of drug ZZZ in the bathing solution if ZZZ enters the red blood cell by protein-facilitated diffusion. The important point is the shape fo the plot. Explain your answer (2 pts) Describe the effect of a blocker of cellular ATP production (e.g. anoxia plus sodium fluoride) on transport rate of ZZZ if transport occurs by active transport, simple diffusion and protein-mediated diffusion. (3 pts)

You are employed at a biotech company, working on a new drug, named ZZZ, which is a sleep aide. Your boss wants to know how this compound moves into red blood cells, and what its concentration will be in red blood cells. He has provided you with plenty of samples of drug ZZZ, and you have the means to measure its concentration (mmol l-1) inside and outside red blood cells, as well as the concentration of any metabolites of drug ZZZ (in case the body can turn ZZZ into other things). He has now asked you for a protocol, and predictions of how the data will come out depending on how ZZZ crosses the red blood cell membrane.

Drug ZZZ may move into red blood cells by simple diffusion through the lipid bilayer. If so, graph the concentration of drug ZZZ inside and outside of the red blood cell vs. time. Assume that when you drop the red blood cells into the bathing solution that they initially contain zero ZZZ. (2 pts).

After five minutes, the concentration of drug ZZZ in the red blood cells is 7 mmoles l-1. What is the rate of entry of drug ZZZ into the red blood cells in units of moles min-1 red blood cell-1 during the first five minutes after placing the red blood cells into the bathing solution. Assume that each red blood cell occupies about 1 x 10-13 liters. Show your work. (2 pts).

Graph rate of entry of ZZZ into the red blood cells (moles min-1 red blood cell-1) vs. the concentration of ZZZ in the bathing solution, assuming ZZZ enters the red blood cells by diffusion. The point is to know the correct shape of the graph. (1 pt).

Drug ZZZ may enter red blood cells by protein-facilitated diffusion. Graph the rate of entry of drug ZZZ into the red blood cells vs. the concentration of drug ZZZ in the bathing solution if ZZZ enters the red blood cell by protein-facilitated diffusion. The important point is the shape fo the plot. Explain your answer (2 pts)

Describe the effect of a blocker of cellular ATP production (e.g. anoxia plus sodium fluoride) on transport rate of ZZZ if transport occurs by active transport, simple diffusion and protein-mediated diffusion. (3 pts)

You are employed at a biotech company, working on a new drug, named ZZZ, which is a sleep aide. Your boss wants to know how this compound moves into red blood cells, and what its concentration will be in red blood cells. He has provided you with plenty of samples of drug ZZZ, and you have the means to measure its concentration (mmol l-1) inside and outside red blood cells, as well as the concentration of any metabolites of drug ZZZ (in case the body can turn ZZZ into other things). He has now asked you for a protocol, and predictions of how the data will come out depending on how ZZZ crosses the red blood cell membrane.

Drug ZZZ may move into red blood cells by simple diffusion through the lipid bilayer. If so, graph the concentration of drug ZZZ inside and outside of the red blood cell vs. time. Assume that when you drop the red blood cells into the bathing solution that they initially contain zero ZZZ. (2 pts).

After five minutes, the concentration of drug ZZZ in the red blood cells is 7 mmoles l-1. What is the rate of entry of drug ZZZ into the red blood cells in units of moles min-1 red blood cell-1 during the first five minutes after placing the red blood cells into the bathing solution. Assume that each red blood cell occupies about 1 x 10-13 liters. Show your work. (2 pts).

Graph rate of entry of ZZZ into the red blood cells (moles min-1 red blood cell-1) vs. the concentration of ZZZ in the bathing solution, assuming ZZZ enters the red blood cells by diffusion. The point is to know the correct shape of the graph. (1 pt).

Drug ZZZ may enter red blood cells by protein-facilitated diffusion. Graph the rate of entry of drug ZZZ into the red blood cells vs. the concentration of drug ZZZ in the bathing solution if ZZZ enters the red blood cell by protein-facilitated diffusion. The important point is the shape fo the plot. Explain your answer (2 pts)

Describe the effect of a blocker of cellular ATP production (e.g. anoxia plus sodium fluoride) on transport rate of ZZZ if transport occurs by active transport, simple diffusion and protein-mediated diffusion. (3 pts)

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