Question

You are studying the function of a newly-identified neuron in the olfactory system of mice. You have established that the membrane is permeable to only two ions, K+ and Na+, with $E_K$ = -80mV and $E_{Na}$ = +50mV. To help plan your next experiments, your colleague proposes a number of hypotheses/predictions. Given the above and what you know about membrane potential control and action potential generation, identify which of these statements is/are TRUE. Select ALL that are TRUE. If the action potentials in this neuron are generated by a classic mechanism involving voltage-dependent Na+ and K+ channels, then increasing the intracellular concentration of Na+ should increase action potential amplitude. If the membrane is equally permeable to K+ and Na+ at the resting potential, then the resting potential should be at -70mV If this neuron expresses ion channels with the appropriate voltage-dependent and time-dependent properties, an action potential could be produced with a hyperpolarizing current stimulus. If the action potentials in this neuron are generated by a classic mechanism involving voltage-dependent Na+ and K+ channels, then the electrogenic effect of increasing the activity of the Na+/K+ ATPase in this neuron would increase the threshold for action potential generation. If you used injected current to set the membrane potential to -90mV, then opening more K+ channels would depolarize the neuron

          You are studying the function of a newly-identified neuron in the olfactory system of
mice. You have established that the membrane is permeable to only two ions, K+ and
Na+, with $E_K$ = -80mV and $E_{Na}$ = +50mV.
To help plan your next experiments, your colleague proposes a number of
hypotheses/predictions. Given the above and what you know about membrane
potential control and action potential generation, identify which of these statements
is/are TRUE.
Select ALL that are TRUE.
If the action potentials in this neuron are generated by a classic mechanism
involving voltage-dependent Na+ and K+ channels, then increasing the
intracellular concentration of Na+ should increase action potential amplitude.
If the membrane is equally permeable to K+ and Na+ at the resting potential,
then the resting potential should be at -70mV
If this neuron expresses ion channels with the appropriate voltage-dependent
and time-dependent properties, an action potential could be produced with a
hyperpolarizing current stimulus.
If the action potentials in this neuron are generated by a classic mechanism
involving voltage-dependent Na+ and K+ channels, then the electrogenic effect
of increasing the activity of the Na+/K+ ATPase in this neuron would increase
the threshold for action potential generation.
If you used injected current to set the membrane potential to -90mV, then
opening more K+ channels would depolarize the neuron

You are studying the function of a newly-identified neuron in the olfactory system of
mice. You have established that the membrane is permeable to only two ions, K+ and
Na+, with EK = -80mV and ENa = +50mV.
To help plan your next experiments, your colleague proposes a number of
hypotheses/predictions. Given the above and what you know about membrane
potential control and action potential generation, identify which of these statements
is/are TRUE.
Select ALL that are TRUE.
If the action potentials in this neuron are generated by a classic mechanism
involving voltage-dependent Na+ and K+ channels, then increasing the
intracellular concentration of Na+ should increase action potential amplitude.
If the membrane is equally permeable to K+ and Na+ at the resting potential,
then the resting potential should be at -70mV
If this neuron expresses ion channels with the appropriate voltage-dependent
and time-dependent properties, an action potential could be produced with a
hyperpolarizing current stimulus.
If the action potentials in this neuron are generated by a classic mechanism
involving voltage-dependent Na+ and K+ channels, then the electrogenic effect
of increasing the activity of the Na+/K+ ATPase in this neuron would increase
the threshold for action potential generation.
If you used injected current to set the membrane potential to -90mV, then
opening more K+ channels would depolarize the neuron

Added by Michael J.

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