Question

You have landed a great new job at a pharmaceutical company. Your job is to develop antibiotics. A key concept in antimicrobial drug development is "selective toxicity," meaning the antimicrobial compound must be more toxic to the microbe than it is to the host. The less toxic the antimicrobial agent is to the host, the more useful it is. You have developed a new compound and have tested its ability to kill (cause mortality) in 2 organisms. Please use the data below to answer the following questions: 100 90 80 70 60 50 40 30 20 10 0 % Mortality 0mM 10mM 20mM 30mM 40mM 50mM 60mM 70mM 80mM 90mM 100mM 110mM 120mM 130mM Moraxella catarrhalis Trichomonas vaginalis Drug Concentration 3. Your research indicates that when 30% of the bacteria have been killed that half of the patients will see their infections drop to a level where their immune systems can clear the infection. You determine that the therapeutic index for this drug is 10. What do you think the TD50 (Toxic Dose 50) is for this drug? Explain or show how you got this number.

          You have landed a great new job at a pharmaceutical company. Your job is to develop antibiotics. A key concept in antimicrobial drug development is "selective toxicity," meaning the antimicrobial compound must be more toxic to the microbe than it is to the host. The less toxic the antimicrobial agent is to the host, the more useful it is. You have developed a new compound and have tested its ability to kill (cause mortality) in 2 organisms. Please use the data below to answer the following questions:

100
90
80
70
60
50
40
30
20
10
0
% Mortality
0mM
10mM
20mM
30mM
40mM
50mM
60mM
70mM
80mM
90mM
100mM
110mM
120mM
130mM
Moraxella catarrhalis
Trichomonas vaginalis
Drug Concentration

3. Your research indicates that when 30% of the bacteria have been killed that half of the patients will see their infections drop to a level where their immune systems can clear the infection. You determine that the therapeutic index for this drug is 10. What do you think the TD50 (Toxic Dose 50) is for this drug? Explain or show how you got this number.

You have landed a great new job at a pharmaceutical company. Your job is to develop antibiotics. A key concept in antimicrobial drug development is "selective toxicity," meaning the antimicrobial compound must be more toxic to the microbe than it is to the host. The less toxic the antimicrobial agent is to the host, the more useful it is. You have developed a new compound and have tested its ability to kill (cause mortality) in 2 organisms. Please use the data below to answer the following questions:

100
90
80
70
60
50
40
30
20
10
0
% Mortality
0mM
10mM
20mM
30mM
40mM
50mM
60mM
70mM
80mM
90mM
100mM
110mM
120mM
130mM
Moraxella catarrhalis
Trichomonas vaginalis
Drug Concentration

3. Your research indicates that when 30% of the bacteria have been killed that half of the patients will see their infections drop to a level where their immune systems can clear the infection. You determine that the therapeutic index for this drug is 10. What do you think the TD50 (Toxic Dose 50) is for this drug? Explain or show how you got this number.

Added by Kathryn D.

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