00:01
Great grouping of questions here.
00:04
The first part asks about insulin's effect on gsk -3 activity.
00:09
So in normal non -mutated healthy cells, insulin inhibits gsk -3 activity.
00:19
And in cells with an insulin receptor mutation, we would expect decreased inhibition.
00:28
Let me do that in different color.
00:32
Inhibition, so we would expect increased gsk3 activity.
00:43
Next few parts ask about atp and its relationship to glycogen phosphorylase activity.
00:51
So in muscle cells, increased concentrations of atp impede or inhibit glycogen phosphorylase activity.
01:00
How does that happen? and why? well, if we are in a state of rest, then we presumably have higher concentrations of atp, and that is one of the stimulants to favor, in this equilibrium, it favors the gp3b form of this enzyme, the b form, which sort of has a closed mouth...