Your aunt Karen can be best described as a post-menopausal woman
with a history of medical issues. You arrive home on break to find
her on the ground and she appears to have suffered a stroke. You
immediately call an ambulance to rush her to the hospital. She is
admitted although her treatment is delayed due to the ongoing
pandemic that has resulted in a lack of medical staff. The
following day, Karen's physician, Dr. Mendes, stops by during his
rounds and to evaluate Karen. She find Karen is ravenous despite
finishing all of her meals and remaining in bed most of the day.
Her daughter (your cousin) states that Karen is requesting to eat
every hour or two, which is very unlike her. Which of the following
is a plausible mechanism that explains Hannah's symptoms?
Please decide whether to accept or reject each statement
AND explain why the statements are either incorrect or why ONE of
the statements should be accepted.
A. Accept/Reject: Karen's stroke could have led to damage to the
hypothalamic CART neurons resulting in greater neuronal
activity.
B. Accept/Reject: Hypoxia caused by the stroke could have
damaged neurons normally responsive to ghrelin.
C. Accept/Reject: The stroke must have damaged the receptor
sites for GLP-1 and PYY.
D. Accept/Reject: Karen's brain damage may render it
hypersensitive to the stimulation of leptin.
E. Accept/Reject: Neurons responsible for CRH secretion might be
overstimulated as a result of the stroke.