Yuzu: Animal Physiology
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BIS 103 - Midterm 1 Lect
6.8: Cofac
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Question 15 of 38
\( { }^{\infty} \) To explore the consequences of coupling ATP hydrolysis under physiological conditions to a thermodynamically unfavorable biochemical reaction, consider the hypothetical transformation \( \mathrm{X} \rightarrow \mathrm{Y} \), for which \( \Delta G^{\prime \circ}=20.0 \mathrm{~kJ} / \mathrm{mol} \).
What is the ratio of \( [\mathrm{Y}] /[\mathrm{X}] \) at equilibrium?
\( [\mathrm{Y}] /[\mathrm{X}]= \) \( \square \)
Suppose X and Y participate in a sequence of reactions during which ATP is hydrolyzed to ADP and \( \mathrm{P}_{\mathrm{i}} \). The overall reaction is
\[
\mathrm{X}+\mathrm{ATP}+\mathrm{H}_{2} \mathrm{O} \rightarrow \mathrm{Y}+\mathrm{ADP}+\mathrm{P}_{\mathrm{i}}
\]
Calculate \( [\mathrm{Y}] /[\mathrm{X}] \) for this reaction at equilibrium. Assume that the temperature is \( 25.0^{\circ} \mathrm{C} \) and the equilibrium concentrations of ATP, ADP, and \( P_{i} \) are 1.00 M each.
\( [\mathrm{Y}][\mathrm{X}]= \) \( \square \)
We know that [ATP], [ADP], and \( \left[\mathrm{P}_{\mathrm{i}}\right] \) are not 1.00 M under physiological conditions. Calculate \( [\mathrm{Y}] /[\mathrm{X}] \) for the ATP-coupled reaction when the values of \( [\mathrm{ATP}],[\mathrm{ADP}] \), and \( \left[\mathrm{P}_{\mathrm{i}}\right] \) are those found in rat myocytes.
\begin{tabular}{|c|c|}
\hline Metabolite & Concentration in rat myocytes (M) \\
\hline ATP & \( 8.05 \times 10^{-3} \) \\
\hline ADP & \( 0.93 \times 10^{-3} \) \\
\hline \( \mathrm{P}_{\mathrm{i}} \) & \( 8.05 \times 10^{-3} \) \\
\hline
\end{tabular}
\( [\mathrm{Y}] / \mathrm{X}]= \) \( \square \)