Question

a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is $70 \%.$ b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is $80 \% ?$

Name: Problem 35, Chapter 21: Organic Chemistry
Uploaded: 2020-10-07T09:40:54-08:00
Duration: 4 min 6 s
Channel: Zubair Abdulla
Description: a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is 70 %. b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is 80 % ?

   a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is $70 \%.$
b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is $80 \% ?$

Organic Chemistry

Paula Yurkanis… 8th Edition

Chapter 21, Problem 35

Instant Answer

Solved by Expert Zubair Abdulla

10/07/2020

Step 1

In the case of bradykinin, which contains 9 amino acids, there are 8 steps of incorporation of an amino acid. Each step has a yield of 70%, or 0.7. Show more…

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a. Calculate the overall yield of bradykinin when the yield for the addition of each amino acid to the chain is $70 \%.$ b. What would be the overall yield of a peptide containing 15 amino acids if the yield for the incorporation of each is $80 \% ?$

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Key Concepts

Multistep Synthesis Efficiency

In multistep synthesis, such as constructing a peptide, the overall yield decreases exponentially with the number of sequential reactions. This concept emphasizes how small inefficiencies at each step can result in a significantly lower yield for longer peptides, which is critical in planning and optimizing synthetic routes.

Stepwise Reaction Yield

Stepwise reaction yield refers to the individual efficiency of each reaction step in a multistep process. In peptide synthesis, if each coupling step has a certain percentage yield, the overall yield of the peptide is the product of these individual yields, meaning that errors in each step multiply, reducing the final yield.

Peptide Synthesis

Peptide synthesis involves the sequential addition of amino acids to build a peptide chain. Each amino acid is added through a coupling reaction, and the efficiency of this process directly affects the final product’s yield.

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