A certain ochre suppressor inserts glutamine in response to the ochre codon. What is the likelie

step 1 The insertion of a base in MRI sequence results in the shift of the frame of the sequence. This

A certain ochre suppressor inserts glutamine in response to...

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Key Concepts

Ochre Codon

An ochre codon is one of the stop codons (specifically UAA) that signals the termination of translation in the genetic code. Its presence in an mRNA sequence typically causes the ribosome to stop protein synthesis, and mutations that create such codons can lead to truncated, nonfunctional proteins.

Suppressor tRNA

A suppressor tRNA is a mutant tRNA that can recognize and decode a stop (nonsense) codon by inserting an amino acid, allowing translation to continue. This type of tRNA effectively 'suppresses' the stop signal caused by a nonsense mutation, thereby restoring the production of a complete polypeptide.

Anticodon Mutation

An anticodon mutation involves a change in the three-nucleotide sequence of the tRNA that base pairs with the mRNA codon during translation. Such a mutation can alter the tRNA’s codon recognition specificity, enabling it to pair with a previously unrecognized codon, such as a stop codon, thereby allowing insertion of an amino acid at a normally terminating position.

tRNA Function in Translation

tRNAs are essential molecules in protein synthesis, responsible for delivering specific amino acids to the ribosome in accordance with codon-anticodon pairing rules on the mRNA. Their accurate matching ensures that the genetic code is correctly translated into the sequence of amino acids in a protein.

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