A gene encodes a protein with the following amino acid...

A gene encodes a protein with the following amino acid sequence: Met-Trp-His-Arg-Ala-Ser-Phe A mutation occurs in the gene. The mutant protein has the following amino acid sequence: Met-Trp-His-Ser-Ala-Ser-Phe An intragenic suppressor restores the amino acid sequence to that of the original protein: Met-Trp-His-Arg-Ala-Ser-Phe Give at least one example of base changes that could produce the original mutation and the intragenic suppressor. (Consult the genct ic code in Figure 15.10.)

A gene encodes a protein with the following amino acid sequence:
Met-Trp-His-Arg-Ala-Ser-Phe
A mutation occurs in the gene. The mutant protein has the following amino acid sequence:
Met-Trp-His-Ser-Ala-Ser-Phe
An intragenic suppressor restores the amino acid sequence to that of the original protein:
Met-Trp-His-Arg-Ala-Ser-Phe
Give at least one example of base changes that could produce the original mutation and the intragenic suppressor. (Consult the genct ic code in Figure 15.10.)

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Key Concepts

Genetic Code

The genetic code is the set of rules that defines how the nucleotide sequence in DNA or RNA is translated into the amino acid sequence of proteins. Understanding the genetic code is essential to determine how specific base changes in codons result in amino acid substitutions.

Intragenic Suppressor Mutation

An intragenic suppressor mutation is a secondary mutation within the same gene that counteracts the effects of a primary mutation, often restoring the original function or sequence of a protein. This type of mutation can compensate for errors by altering neighboring codons or reading frames to reestablish the correct amino acid sequence.

Missense Mutation

A missense mutation is a point mutation where a single nucleotide change results in a codon that encodes a different amino acid. This type of mutation can alter the protein’s structure and function if the substitution affects a critical region of the protein.

Codons

Codons are three-nucleotide sequences in mRNA that specify which amino acid will be added next during protein synthesis. Due to the degeneracy of the genetic code, different codons can encode the same amino acid, which is crucial when considering how mutations or suppressor mutations might alter, or restore, protein sequences.

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