A man with hemophilia marries a woman who has normal...

Name: Problem 7, Chapter 3: SAT Biology E/M
Uploaded: 2020-01-18T20:54:20-08:00
Duration: 4 min 18 s
Channel: Ricajoy Montero
Description: A man with hemophilia marries a woman who has normal hemoglobin and is not a carrier. Which of the following is true? (A) None of their children will have the disease nor will they be carriers. (B) All the boys will have the disease. (C) All the girls will have the disease. (D) All the boys will be carriers. (E) All the girls will be carriers.

A man with hemophilia marries a woman who has normal hemoglobin and is not a carrier. Which of the following is true? (A) None of their children will have the disease nor will they be carriers. (B) All the boys will have the disease. (C) All the girls will have the disease. (D) All the boys will be carriers. (E) All the girls will be carriers.

A man with hemophilia marries a woman who has normal hemoglobin and is not a carrier. Which of the following is true?
(A) None of their children will have the disease nor will they be carriers.
(B) All the boys will have the disease.
(C) All the girls will have the disease.
(D) All the boys will be carriers.
(E) All the girls will be carriers.

Key Concepts

X-linked Recessive Inheritance

X-linked recessive inheritance refers to genetic conditions that are caused by mutations located on the X chromosome. In these disorders, males, who have only one X chromosome, are generally more likely to express the disease if they inherit a mutated gene, whereas females, having two X chromosomes, typically become asymptomatic carriers unless both copies are affected.

Hemophilia

Hemophilia is a classic example of an X-linked recessive disorder. It is a bleeding disorder caused by the deficiency of clotting factors and illustrates how mutations on the X chromosome can have significant effects on disease manifestation, particularly in males due to their single X chromosome.

Carrier Status in X-linked Conditions

Carrier status in X-linked conditions refers to individuals, usually females, who possess one copy of the mutated gene along with one normal gene. Carriers usually do not exhibit disease symptoms because the normal gene can compensate, but they can still pass the mutated gene to their offspring, influencing the inheritance pattern of the disorder.

Hemizygosity

Hemizygosity is the state of having only one allele of a gene in a diploid organism, as seen in males for genes located on the X chromosome. This means that if a male inherits a defective gene on his X chromosome, there is no second copy to mask the effect, making him more susceptible to expressing X-linked disorders.

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