00:01
Okay, we're going to answer this question, we have to make a panel discredit.
00:03
Remember that hemophilia is an ex -linked, recessive disease.
00:12
Okay, so let's state the allele.
00:13
Imagine this is the normal allele.
00:15
This is the mutant allele.
00:17
So, this is the normal allele, and this is the mutant allele for amophilia.
00:24
Then we can have the following possibilities for the genotypes and phenotypes.
00:27
This is going to be a normal female, okay, because she has two normal x chromosomes.
00:32
This is going to be also a normal female, okay? because a series of x -linkal recessive, females are going to need two mutant x chromosomes in order to develop the disease.
00:45
However, only one mutant x chromosome is going to develop a normal female, but she's going to be a cagler.
00:51
Then we have a almost -sary recessive for the mutant allele and this is going to be a female with emmophilia.
01:02
Okay, and what about males? well, males only have one excromatoseph.
01:05
So this is going to be a normal male and whenever they have their x chromosome mutant, they are going to be a male with hemophilia.
01:14
So it says a man with hemophilia, it means with this genotype, mag is a woman who has normal imoglobin and is not a cover.
01:25
So the genotype for the female is this.
01:28
Which is the following is true.
01:29
Well, let's make a panel square first.
01:31
Here you place the female, the normal female, the healthy female.
01:35
Female and here i'm going to place the hemophilia mag.
01:42
So you just cross this and this.
01:46
So you have all of these possibilities...