Alleles A and a are at a locus on the same chromosome as is...

Alleles $A$ and $a$ are at a locus on the same chromosome as is a locus with alleles $B$ and $b$. Aa $B b$ is crossed with aa bb and the following progeny are produced: $$\begin{array}{lr}\text {Aa Bb} & 5 \\\text {Aa bb} & 45 \\\text {aa Bb} & 45 \\ \text {aa bb} & 5\end{array}$$ What condusion can be made about the arrangement of the genes on the chromosome in the Aa $B b$ parent?

Alleles $A$ and $a$ are at a locus on the same chromosome as is a locus with alleles $B$ and $b$. Aa $B b$ is crossed with aa bb and the following progeny are produced: $$\begin{array}{lr}\text {Aa Bb} & 5 \\\text {Aa bb} & 45 \\\text {aa Bb} & 45 \\ \text {aa bb} & 5\end{array}$$
What condusion can be made about the arrangement of the genes on the chromosome in the Aa $B b$ parent?

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Key Concepts

Genetic Linkage

Genetic linkage refers to the tendency of genes that are located close together on the same chromosome to be inherited together. Because they are physically connected, the alleles at these loci do not assort independently during meiosis, which alters the expected ratios of offspring genotypes compared to unlinked genes.

Recombination Frequency

Recombination frequency is the measure of how often recombination occurs between two gene loci during meiosis. It is used to estimate the physical distance between genes on a chromosome; closely linked genes show a low recombination frequency since crossovers between them are rare, while genes further apart tend to have higher frequencies of recombination.

Cis (Coupling) Configuration

In the cis or coupling configuration, the alleles for the two genes are arranged so that the dominant (or specific) alleles are on one chromosome, and the recessive (or alternative) alleles are on the homologous chromosome. This arrangement causes the parental gametes (those retaining the original allele combinations) to appear in greater numbers compared to the recombinant gametes, which result from the rare crossover events.

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