Question

Before LTP: In the normal state, what is the effect of glutamate at the AMPA receptors? At the NMDA receptors?

   Before LTP: In the normal state, what is the effect of glutamate at the AMPA receptors? At the NMDA receptors?

Biological Psychology

Biological Psychology

James W. Kalat 12th Edition

Chapter 12, Problem 15

Instant Answer

Solved by Expert Danielle Ashley

05/10/2021

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Before LTP: In the normal state, what is the effect of glutamate at the AMPA receptors? At the NMDA receptors?

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Key Concepts

AMPA Receptors

AMPA receptors are ionotropic glutamate receptors that mediate the rapid, initial phase of excitatory synaptic transmission by allowing sodium ion influx when activated by glutamate. This results in a quick depolarization of the postsynaptic neuron, which is essential for normal synaptic signaling before any synaptic strengthening occurs.

NMDA Receptors

NMDA receptors are a subtype of ionotropic glutamate receptors characterized by their voltage-dependent magnesium block. In the resting state, even when glutamate binds to these receptors, the channel remains largely inactive due to this magnesium block, preventing calcium and sodium entry until sufficient depolarization occurs to relieve the block.

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