00:01
For this question, it's important to note how histones function and how these can be sort of circumnavigated in order to increase the activity of dna transcription.
00:13
So here we have this special protein of gala vp16.
00:19
And we are told that this is going to bind the dna itself and increase the rate at which it is transcribed.
00:27
So if you imagine a dna strand, this is going to consist of, multiple portions, one of which will include, say, an enhancement region, which is going to increase the rate at which the dna strand is transcribed by the rna polymerase.
00:46
So you can imagine that because the gala vp 16 is going to increase the rate at which your dna strand is transcribed, that perhaps this gala vp 16 is going to bind to that enhancement region and cause the upregulation of the genes in this sequence.
01:07
From there, you have to propose why the histones might be blocked because of this.
01:13
So here we can go over the role of histones.
01:18
These are specialized proteins inside the nucleus of the cell that rely on ravelling and twisting dna around their own proteins.
01:29
And this is going to help condense that dna inside of the nucleus...