00:01
Okay, so this question is just asking us about the causes of cancer.
00:06
So the first answer choice, which is a, is referring to genetic mutations.
00:18
So as far as genetic mutations go, we know that there are two types of genetic mutations.
00:29
The first one is that proto -oncogenes can become oncogenes.
00:38
And we know that proto -oncogenes are responsible for promoting the cell cycle and decreasing apoptosis.
01:00
And so when they are mutated, it is called a gain -of -function mutation.
01:06
And so in proto -onchicines, a gain of function mutation can result in the overproduction of cyclin, which means that cyclin is going to be readily available all the time.
01:40
And then, basically, when these proto -onco -greens become mutated, it can result in receptor proteins that are really easy to activate and can be simulated by growth factor produced by the receiving cell.
02:06
So essentially it is just going to result in unrestrained cell cycle and lack of apoptosis.
02:22
And so you can see how that would be basically good for cancer formation because you aren't restraining the cell cycle.
02:34
All and then you have this lack of cell death.
02:37
And then we know that tumor suppressor genes can just become inactive.
02:49
Oh, i'm sorry.
02:52
And so if we think back, we know that these tumor suppressor genes basically do the opposite of what proto -onco genes do.
03:02
So they decrease or inhibit the cell cycle and increase apoptosis.
03:21
And these are called loss of function mutations because basically it means that their products don't inhibit the cell cycle anymore or promote apoptosis.
03:42
So this is similar to the last one or we're just going to see that unrestrained still cycle and not about that...