Question
Describe and give the results of an experiment that shows the importance of the IRE in the ferritin mRNA to iron inducibility of ferritin production.
Step 1
It plays a crucial role in regulating the translation of ferritin mRNA in response to iron levels in the cell. When iron levels are low, an iron regulatory protein (IRP) binds to the IRE, blocking the translation of the mRNA into ferritin. When iron levels are Show more…
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Consider an experiment in which an iron-response element (IRE) was added to a gene that is not normally regulated by iron levels. Select a possible effect of adding an IRE at the 3' end of the gene: - High iron levels will promote mRNA degradation. - Low iron levels will promote translation. - Low iron levels will block translation. - High iron levels will promote mRNA stabilization.
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