00:01
So the question asks us to explain how prokaryotes and eukaryotes overcome the problem of a stalled ribosome that has run into the end of an mrna where there isn't a stop codon.
00:13
So it isn't like the protein isn't exiting the ribosome and floating away.
00:18
It's just stuck and the messenger rna is still stuck in the e &p sites, but there's an empty a site.
00:27
Prokaryotes solve this problem using transfer messenger rna, which is a weird, combination of a bit of mrna, and also it comes along with its own amino acid.
00:41
And so the amino acid comes along and is able to be attached to whatever is currently in the p site, and then the ribosome can continue reading the mrna that came along with it, and so it's able to get unstalled.
00:56
But the sequence of what that mrna codes for is a specific sequence that tells, the cell that this protein did not get translated correctly and that it will not be a functional protein and that it needs to be degraded once it is released...