00:01
This question asks, why does translation terminate when the ribosome reaches a stop codon? what happens? so we have to understand that there is no t rna that will recognize a stop codon.
00:17
However, the ribosome itself will be able to recognize that a stop codon has been reached and thus a release factor, as illustrated here, will bind to that a site in the ribosome, and specifically the large ribosomal subunit.
00:34
Because remember, if we are to look at this large ribosomal subunit here, we remember that there are three spaces for trna to bind.
00:44
There is the e site, the p site, and the a site.
00:49
So the a site is where the trna will enter.
00:53
And so in this case, we see that the release factor will enter that a site.
00:58
And once that release factor has entered that a site, the large ribosomal subunit will basically release this trna that is in the p site, so the trna will leave, and the peptide, the growing peptide chain right here will also be released, unless we see our free polypeptide chain or our free protein...