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How many $\mathrm{Mg}^{2+}$ ions are proposed to participate in catalysis at the active center of RNA polymerases? Why is one of these metal ions difficult to see in the crystal structure of yeast RNA polymerase II?
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It is proposed that two $\mathrm{Mg}^{2+}$ ions participate in the catalytic process of RNA polymerases. Show more…
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Option D: Consider the mechanism of the enzyme enolase as discussed in lecture (figure below): (a) There is a Mg2+ in the active site, which appears to be participating in the reaction. What type of catalysis is this? (b) What is one role of the Mg2+ -- what is it doing to help the enzyme to catalyze the reaction? Explain briefly. (c) Considering your answer to "b" above, what would be the effect on kcat OR the Km (as appropriate) if the Mg2+ was missing? (perhaps it was removed from solution by chelation). Explain your answer.
(Chemical Connections $22 \mathrm{C}$ ) What role does $\mathrm{Mn}^{2+}$ play in anchoring the substrate in the active site of protein kinase?
(Chemical Connections $23 \mathrm{C}$ ) What role does $\mathrm{Mn}^{2+}$ play in anchoring the substrate in the active site of protein kinase?
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