R-CH2-CH2 OH can be converted into RCH2 CH2 COOH . The correct sequence of reagent is (a) PBr3,

step 1 In this problem the reaction will happen something like this. Just look at it carefully. R. CS2

R-CH2-CH2 OH can be converted into RCH2 CH2 COOH . The...

$\mathrm{R}-\mathrm{CH}_2-\mathrm{CH}_2 \mathrm{OH}$ can be converted into $\mathrm{RCH}_2 \mathrm{CH}_2$ COOH . The correct sequence of reagent is (a) $\mathrm{PBr}_3, \mathrm{KCN}, \mathrm{H}^{+}$ (b) $\mathrm{HCN}, \mathrm{PBr}_3, \mathrm{H}^{+}$ (c) $\mathrm{KCN}, \mathrm{H}^{+}$ (d) $\mathrm{PBr}_3, \mathrm{KCN}, \mathrm{H}_2$

$\mathrm{R}-\mathrm{CH}_2-\mathrm{CH}_2 \mathrm{OH}$ can be converted into $\mathrm{RCH}_2 \mathrm{CH}_2$ COOH . The correct sequence of reagent is
(a) $\mathrm{PBr}_3, \mathrm{KCN}, \mathrm{H}^{+}$
(b) $\mathrm{HCN}, \mathrm{PBr}_3, \mathrm{H}^{+}$
(c) $\mathrm{KCN}, \mathrm{H}^{+}$
(d) $\mathrm{PBr}_3, \mathrm{KCN}, \mathrm{H}_2$

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Key Concepts

Alcohol Activation via Halogenation

This concept involves converting an alcohol into a more reactive alkyl halide by replacing the hydroxyl group with a halogen atom using reagents such as phosphorus tribromide (PBr3). This transformation is crucial as it creates a better leaving group, facilitating further substitution reactions.

Nucleophilic Substitution Mechanism

Nucleophilic substitution (typically an SN2 reaction) is a process in which a nucleophile replaces a leaving group in an organic molecule. In this context, the halide from the activated alcohol is replaced by a cyanide ion (CN-) from potassium cyanide (KCN), resulting in the formation of a nitrile derivative.

Nitrile Hydrolysis to Carboxylic Acids

This key concept explains the conversion of nitriles into carboxylic acids through hydrolysis. Under acidic conditions, the nitrile group is transformed, typically via an intermediate amide, ultimately yielding a carboxylic acid. This reaction pathway is valuable in organic synthesis for introducing carboxylic acid functionality.

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