Select the true statements from the following. (1) Insulin...

Name: Problem 59, Chapter 12: Objective Biology for NEET
Uploaded: 2021-11-21T07:50:53-08:00
Duration: 1 min 21 s
Channel: Hast Aggarwal
Description: Select the true statements from the following. (1) Insulin from animal source, may develop allergy in some patients. (2) C-peptide is not present in mature insulin. (3) Recombinant therapeutics do not induce unwanted immunological response. (4) Insulin can be administered orally to diabetic patients (a) 1 and 3 only (b) 1 and 2 only (c) 3 and 4 only (d) 1,2 and 3 only

Select the true statements from the following. (1) Insulin from animal source, may develop allergy in some patients. (2) C-peptide is not present in mature insulin. (3) Recombinant therapeutics do not induce unwanted immunological response. (4) Insulin can be administered orally to diabetic patients (a) 1 and 3 only (b) 1 and 2 only (c) 3 and 4 only (d) 1,2 and 3 only

Select the true statements from the following.
(1) Insulin from animal source, may develop allergy in some patients.
(2) C-peptide is not present in mature insulin.
(3) Recombinant therapeutics do not induce unwanted immunological response.
(4) Insulin can be administered orally to diabetic patients
(a) 1 and 3 only
(b) 1 and 2 only
(c) 3 and 4 only
(d) 1,2 and 3 only

Key Concepts

Insulin Biosynthesis and C-Peptide

Insulin is initially synthesized as a larger precursor molecule known as proinsulin, which contains the connecting peptide (C-peptide). During the conversion to mature insulin, proinsulin is cleaved to remove the C-peptide, leaving behind the active hormone. This process is fundamental to our understanding of insulin production and is also used in clinical diagnostics to assess endogenous insulin secretion.

Limitations in Oral Administration of Protein Drugs

Protein drugs, such as insulin, are typically administered through injections because the gastrointestinal tract contains enzymes that degrade proteins. This degradation, coupled with poor absorption, makes it challenging for orally administered proteins to reach systemic circulation in an active form. Research continues in the field of drug delivery to overcome these obstacles, but currently, the parenteral route remains the most effective for such therapeutics.

Immunogenicity in Protein Therapeutics

This concept involves understanding that proteins used as therapeutics, especially those derived from animal sources, have the potential to evoke an immune response in the human body. Such responses can lead to allergic reactions or the development of antibodies that reduce the effectiveness of the treatment. Immunogenicity is a crucial consideration in the design and application of protein-based drugs, including those formulated through recombinant DNA technology.

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