Question

Simulate the model in Eqs. (8.114) and (8.115) given that $q_S(0)=20, q_E(0)=0.01, K_1=6$, $K_{-1}=0.1, K_2=10, K_3=5, K_{-3}=0.05, K_4=7$, and $q_l(0)=5$. All other initial quantities are zero.

   Simulate the model in Eqs. (8.114) and (8.115) given that $q_S(0)=20, q_E(0)=0.01, K_1=6$, $K_{-1}=0.1, K_2=10, K_3=5, K_{-3}=0.05, K_4=7$, and $q_l(0)=5$. All other initial quantities are zero.
 
Introduction to Biomedical Engineering
Introduction to Biomedical Engineering
John Enderle, Joseph… 3rd Edition
Chapter 8, Problem 36 ↓

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The given model equations are: $\frac{dq_S}{dt} = K_{-1}q_E - K_1q_S$ $\frac{dq_E}{dt} = K_1q_S - K_{-1}q_E - K_2q_E + K_3q_l$ $\frac{dq_l}{dt} = K_2q_E - K_3q_l - K_{-3}q_l + K_4q_l$  Show more…

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Simulate the model in Eqs. (8.114) and (8.115) given that $q_S(0)=20, q_E(0)=0.01, K_1=6$, $K_{-1}=0.1, K_2=10, K_3=5, K_{-3}=0.05, K_4=7$, and $q_l(0)=5$. All other initial quantities are zero.
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Key Concepts

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Numerical Simulation
Numerical simulation involves using computational methods to approximate the solutions of mathematical models, especially when analytical solutions are difficult or impossible to obtain. In the context of dynamical systems modeled by differential equations, numerical integration techniques such as Runge-Kutta methods are commonly employed. These techniques allow for the step-by-step calculation of the system’s state over time, enabling the study of its behavior under various conditions.
Rate Constants and Parameters
Rate constants and other parameters are numerical values that quantify the speeds and strengths of interactions or reactions within a system. These constants, often derived from experimental data or theoretical analysis, determine how quickly reactions occur in a kinetic model. They are integral to making simulations realistic and ensuring that the model reflects the underlying dynamics observed in practical scenarios.
Dynamical Systems
Dynamical systems are mathematical models that describe how the state of a system evolves over time. They are typically represented by differential or difference equations that capture the relationships among various system variables and their rates of change. This concept is fundamental in understanding how different components of a system interact and evolve in processes such as chemical reactions, biological interactions, or physical phenomena.
Initial Conditions
Initial conditions refer to the starting values of the system's variables at the beginning of the simulation. In the context of differential equations, these values are essential because they determine the particular trajectory or solution of the system over time. Without appropriate initial conditions, the behavior of the dynamical system cannot be accurately predicted or simulated.

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