00:01
This question is asking us about the diversity of antibodies and where that comes from.
00:08
And in a sense, what we're really asking about is the diversity of b cells.
00:15
Because you have to remember that each mature b cell only makes one kind of antibody.
00:21
So every antibody produced by that b cell is identical.
00:26
If you have two b cells that have different origins, they have different antibodies.
00:31
Where do we get this diversity of b cells? and it comes from the rearrangement of the genes that are involved in building the antibody proteins.
00:44
So it involves the rearrangement of the genes.
00:57
So in humans, and in particular we're talking about naive b cells, b cells that are just developing, the genes that they need for building antibody proteins are arranged in clusters along chromosomes.
01:17
And you typically have a few clusters, and there are multiple genes in each of these clusters, and each gene in these clusters do more or less the same thing or the same part of the, they transcribe the same protein.
01:37
But they are a little bit different in how they look...