Which of the following are involved in posttranscriptional control? a. control of RNA splicing b

Which of the following are involved in posttranscriptional...

Key Concepts

Posttranslational Regulation

Posttranslational regulation involves modifications that occur to proteins after they have been synthesized during translation. These modifications, which include processes such as ubiquitination, proteolytic cleavage, and phosphorylation, alter protein function, localization, stability, and interactions, distinguishing them from the RNA-level controls found in posttranscriptional regulation.

RNA Splicing

RNA splicing is a key component of posttranscriptional regulation where introns are removed and exons are joined together from a pre-mRNA transcript. This process not only ensures that the mRNA can be translated into a functional protein, but it also contributes to protein diversity through the generation of different mRNA variants from the same gene.

Posttranscriptional Regulation

Posttranscriptional regulation refers to the control of gene expression that occurs after RNA has been synthesized. This process includes a variety of modifications and processing events, such as the removal of introns, addition of a 5' cap, polyadenylation, editing, and transport of mRNA, all of which determine the stability, localization, and translation efficiency of the RNA molecule.

Transcript

00:01 Here we are talking about different factors of post -transcriptional regulation or control.

00:07 So as the word indicates, this is going to be anything that occurs after the transcription of the mrna.

00:16 So you can imagine that you have your dna strand with the gene of interest, and your polymerases will cause the creation of what we call the pre -mrna strand.

00:30 That pre -mrna is going to undergo processing inside the nucleus in order to be converted into the finalized m rna strand.

00:43 And that, of course, can go through the process of translation and the ribosomes in order to create your protein.

00:54 So here, when we talk about this post -transcriptional regulation, we are talking about this processing step.

01:02 To change the pre -m rna to the m rna strand.

01:06 So that's going to include a few modifications.

01:10 It's going to include the addition of a cap to one end of the rna and the addition of a polya tail.

01:18 And those are going to allow it to survive better in the cytoplasm where you have digestive enzymes that we would call rnaases.

01:29 So these polya tail and caps would prevent the rnaase from digesting the important end of the mrna strand.

01:39 And the cap allows it to be recognized in the ribosome as well.

01:44 In addition to those, processing is also going to include the process of alternative splicing...

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