You have isolated C57BL/6 embryonic stem cells and have tried a new culture condition to keep them pluripotent. To test for the success of your culture protocol, you are injecting the cells into a C57BL/6 blastocyst. Once the pups are born, you notice that your experiment failed. Why? HINT: It's related to chimera creation. (Donor blastocyst of a black fur mom vs. white fur foster mom. Foster mom will donate the blastocyst, and we will inject the derived ESC (ESL) of the donor mom into the blastocyst. We then implant it back to the foster mom and for the 1st generation of a chimera.)