Q1. If the frequency of the HbS allele is 0.6 in a population, what is the frequency of the HbA allele (assuming this is a two-allele system)?
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Q2. In the case study in this lab, which genotype is represented by "2pq" in the Hardy-Weinberg equation?
Homozygous HbA
Homozygous HbS
Heterozygous HbA/HbS
No specific genotype
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Q3. In a population, if the proportion of individuals who have sickle-cell disease is 0.10, and the population is assumed to be at Hardy-Weinberg equilibrium,
what is the expected frequency of the HbS allele? (Hint: What is the genotype of people with sickle-cell disease, and how is that genotype represented in the
Hardy-Weinberg equation?)
0.32
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0.18
0.90
0.01
Q4. In a population where the proportion of individuals who are susceptible to malaria (genotype HbA/HbA) is 0.70, and the population is assumed to be at
Hardy-Weinberg equilibrium, what proportion of the population should be heterozygous HbA/HbS?
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