Question

1. Cystic fibrosis is a relatively common (1 in 2000 live births) genetic disease of Caucasians. Although it affects many organs, pulmonary obstruction is a major problem. CF patients have reduced Cl 2 permeability and the disease can be diagnosed by elevated [Cl 2] in sweat. Genetic mutations lead to defects in cystic fibrosis transmembrane conductance regulator (CFTR) protein which is a cAMP-dependent Cl 2 channel. CFTR has structural homology to the superfamily of ATP-binding cassette (ABC) transporters. ATP-binding cassette (ABC) transporters: a. have both a membrane-spanning domain that recognizes the substrate and an ATP-binding domain b. all have two functions: forming a channel and conductance regulation c. all effect translocation by forming channels d. are found only in eukaryotes e. are all P-glycoproteins

          1. Cystic fibrosis is a relatively common (1 in 2000 live
births) genetic disease of Caucasians. Although it affects many
organs, pulmonary obstruction is a major problem. CF patients have
reduced Cl 2 permeability and the disease can be diagnosed by
elevated [Cl 2] in sweat. Genetic mutations lead to defects in
cystic fibrosis transmembrane conductance regulator (CFTR) protein
which is a cAMP-dependent Cl 2 channel. CFTR has structural
homology to the superfamily of ATP-binding cassette (ABC)
transporters.
ATP-binding cassette (ABC)
transporters: 
a. have both a membrane-spanning domain that recognizes the
substrate and an ATP-binding domain
b. all have two functions: forming a channel and conductance
regulation
c. all effect translocation by forming channels
d. are found only in eukaryotes
e. are all P-glycoproteins

Added by Alberto A.

Question

Please give Ace some feedback