Question

2. The following DNA sequence is a small part of the coding (nontemplate) strand from the open reading frame of the ?-hemoglobin gene. Given the codon chart listed below, what would be the effect of a mutation that deletes the G at the beginning of the DNA sequence? 5' - GTT TGT CTG TGG TAC CAC GTG GAC TGA - 3' Second Base in Codon U C A G U UUU} Phe UCU} Ser UAU} Tyr UGU} Cys U UUC UCC UAC UGC C UUA} Leu UCA UAA Stop UGA Stop A UUG UCG UAG Stop UGG Trp G C CUU} Leu CCU} Pro CAU} His CGU} Arg U CUC CCC CAC CGC C CUA CCA CAA} Gln CGA A CUG CCG CAG CGG G A AUU} Ile ACU} Thr AAU} Asn AGU} Ser U AUC ACC AAC AGC C AUA ACA AAA} Lys AGA} Arg A AUG Met or ACG AAG AGG G Start G GUU} Val GCU} Ala GAU} Asp GGU} Gly U GUC GCC GAC GGC C GUA GCA GAA} Glu GGA A GUG GCG GAG GGG G (A) The mutation precedes the gene, so no changes would occur. (B) Lysine (lys) would replace glutamine (gln), but there would be no other changes. (C) The first amino acid would be missing, but there would be no other change to the protein. (D) The reading frame of the sequence would shift, causing a change in the amino acid sequence after that point.

          2. The following DNA sequence is a small part of the coding (nontemplate) strand from the open reading frame of the ?-hemoglobin gene. Given the codon chart listed below, what would be the effect of a mutation that deletes the G at the beginning of the DNA sequence?

5' - GTT TGT CTG TGG TAC CAC GTG GAC TGA - 3'

Second Base in Codon
U C A G
U UUU} Phe UCU} Ser UAU} Tyr UGU} Cys U
UUC UCC UAC UGC C
UUA} Leu UCA UAA Stop UGA Stop A
UUG UCG UAG Stop UGG Trp G
C CUU} Leu CCU} Pro CAU} His CGU} Arg U
CUC CCC CAC CGC C
CUA CCA CAA} Gln CGA A
CUG CCG CAG CGG G
A AUU} Ile ACU} Thr AAU} Asn AGU} Ser U
AUC ACC AAC AGC C
AUA ACA AAA} Lys AGA} Arg A
AUG Met or ACG AAG AGG G
Start
G GUU} Val GCU} Ala GAU} Asp GGU} Gly U
GUC GCC GAC GGC C
GUA GCA GAA} Glu GGA A
GUG GCG GAG GGG G

(A) The mutation precedes the gene, so no changes would occur.
(B) Lysine (lys) would replace glutamine (gln), but there would be no other changes.
(C) The first amino acid would be missing, but there would be no other change to the protein.
(D) The reading frame of the sequence would shift, causing a change in the amino acid sequence after that point.

2. The following DNA sequence is a small part of the coding (nontemplate) strand from the open reading frame of the ?-hemoglobin gene. Given the codon chart listed below, what would be the effect of a mutation that deletes the G at the beginning of the DNA sequence?

5' - GTT TGT CTG TGG TAC CAC GTG GAC TGA - 3'

Second Base in Codon
U C A G
U UUU Phe UCU Ser UAU Tyr UGU Cys U
UUC UCC UAC UGC C
UUA Leu UCA UAA Stop UGA Stop A
UUG UCG UAG Stop UGG Trp G
C CUU Leu CCU Pro CAU His CGU Arg U
CUC CCC CAC CGC C
CUA CCA CAA Gln CGA A
CUG CCG CAG CGG G
A AUU Ile ACU Thr AAU Asn AGU Ser U
AUC ACC AAC AGC C
AUA ACA AAA Lys AGA Arg A
AUG Met or ACG AAG AGG G
Start
G GUU Val GCU Ala GAU Asp GGU Gly U
GUC GCC GAC GGC C
GUA GCA GAA Glu GGA A
GUG GCG GAG GGG G

(A) The mutation precedes the gene, so no changes would occur.
(B) Lysine (lys) would replace glutamine (gln), but there would be no other changes.
(C) The first amino acid would be missing, but there would be no other change to the protein.
(D) The reading frame of the sequence would shift, causing a change in the amino acid sequence after that point.

Added by Rosa S.

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