Question 5 Examine the following sequence: 5'-AUG GGG ACG UGU AGA UGA-3' Now, imagine that the first codon has had a mutation and the G has been changed to a U. What is the effect of this mutation on transcription and translation of this gene, if any? Second letter U C A G UUU UCU UAU UGU U UUC Phe UCC UAC Tyr UGC Cys C UUA Leu UCA Ser UAA Stop UGA Stop A UUG UCG UAG Stop UGG Trp G CUU CCU CAU His CGU U CUC Leu CCC Pro CAC CGC Arg C CUA CCA CAA Gln CGA A CUG CCG CAG CGG G AUU ACU AAU Asn AGU Ser U AUC Ile ACC Thr AAC AGC C AUA ACA AAA Lys AGA Arg A AUG Met ACG AAG AGG G GUU GCU GAU Asp GGU U GUC Val GCC Ala GAC GGC Gly C GUA GCA GAA Glu GGA A GUG GCG GAG GGG G First letter Third letter The protein will start with Ile instead of Met No protein will be formed The frame of the protein will be shifted and the amino acid sequence will change There will be no change in transcription and translation
Added by Ashlee P.
Close
Step 1
Step 1: The original sequence is 5'AUG GGG ACG UGU AGA UGA-3". Show more…
Show all steps
Your feedback will help us improve your experience
Krishna G and 63 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
The following DNA sequence is a small part of the coding (nontemplate) strand from the open reading frame of the beta-hemoglobin gene. Given the codon chart listed below, what would be the effect of a mutation that deletes the G at the beginning of the DNA sequence? 5' - GTT TGT CTG TGG TAC CAC GTG GAC TGA - 3' (A) The mutation precedes the gene, so no changes would occur. (B) Lysine (lys) would replace glutamine (gln), but there would be no other changes. (C) The first amino acid would be missing, but there would be no other change to the protein. (D) The reading frame of the sequence would shift, causing a change in the amino acid sequence after that point.
Sri K.
Consider the following mRNA sequence and answer the following questions : 5'-AUUGCUAUGGAUAGCUGGGGCUGAAAAAAAAAAAAAAAA-3' 1. What is the amino acid sequence that this mRNA will generate? 2. If the underlined G were changed to an A, would the above sequence be altered and if so in what way?
Bryan V.
Below are several DNA sequences that are mutated compared with the wild-type sequence: $3^{\prime}-\mathrm{T} \mathrm{A} \mathrm{C} \mathrm{T} \mathrm{G} \mathrm{A}$ C T G A C G A T C-5'. Envision that each is a section of a DNA molecule that has separated in preparation for transcription, so you are only seeing the template strand. Construct the complementary DNA sequences (indicating 5' and 3' ends) for each mutated DNA sequence, then transcribe (indicating 5' and 3' ends) the template strands, and translate the mRNA molecules using the genetic code, recording the resulting amino acid sequence (indicating the $\mathrm{N}$ and C termini). What type of mutation is each? Mutated DNA Template Strand #1: 3'-T A C T G T C T G A C G A T C-5' Complementary DNA sequence:mRNA sequence transcribed from template:Amino acid sequence of peptide:Type of mutation: Mutated DNA Template Strand #2: 3'-T A C G G A C T G A C G A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation: Mutated DNA Template Strand #3: 3'-T A C T G A C T G A C T A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation: Mutated DNA Template Strand #4: 3'-T A C G A C T G A C T A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation:
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD