1. Who invented “DNA fingerprints? 2. Who demonstrates how DNA sequencing was done before 1990? 3. What is linkage mapping? How is it used to identify genes? Explain. 4. Who is speeding up the HGP? 5. How are the 2 different approaches to sequence the human genome different? Explain. 6. Who put an end to the race and demanded a draft of the HGP to be delivered by the rivaling parties? 7. Scientists estimated (in 2001) that the human genome about contains ____ genes. How many genes are believed to be in the human genome today? 8. What is gene annotation? 9. What is an open reading frame? 10. What is junk DNA and why it is important?
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**Alec Jeffreys** invented DNA fingerprints. Show more…
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Q1) Sequencing of the human genome has revealed much about the organization of genes. Describe the differences between solitary genes, gene families, and pseudogenes. Q2) Much of the human genome consists of repetitive DNA. Describe the difference between microsatellite and minisatellite DNA. How is the repetitive DNA useful for identifying individuals by the technique of DNA fingerprinting? Q3) Multiple protein isoforms can be generated from a single eukaryotic gene. Describe the process that leads to this variability. Q4) What are the transcription regulatory sequences in eukaryotes? Describe their functions.
1. What do you want to learn, if anything, about your own genome? 2. Until recently, the Basque people of Europe were thought to have descended directly from hunter-gatherers, based on language similarities. Why is shared DNA information a more reliable indicator of ancestry than shared language? 3. Describe both a frivolous use and a serious use of DNA testing. 4. Explain why exome sequencing can be almost as valuable as genome sequencing. 5. DNA samples are taken from inside the cheeks of people arrested on suspicion of having committed serious crimes. Only a small portion of the genome information is recorded (13 repeated sequences that do not encode proteins; and the DNA itself is discarded. Explain why sampling this part of the genome does not indicate anything about the person's health, ancestry, or traits. 6. Make up a crime scene scenario (or find a real one) in which DNA from a nonhuman provided critical evidence.
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