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14. Glomerular Filtration Rate (GFR) is the rate at which filtrate (and therefore urine) is produced. Your blood pressure varies on a daily basis for a variety of reasons, and this affects GFR: high blood pressure = high GFR (because blood is "pushing harder" on the walls of the glomerular capillaries, like a hose turned on high), low blood pressure = low GFR. In spite of these changes in blood pressure, your kidneys are able to compensate and maintain a relatively constant GFR, and thus a relatively constant production of urine. Under NORMAL conditions (blood pressure not too low or too high), GFR (and therefore urine production) is maintained by the juxtaglomerular apparatus (JGA), through a process called renal autoregulation. In the diagram below, LABEL the components of the JGA (afferent arteriole, granular cells, distal convoluted tubule (DCT), macula densa) and draw an ARROW pointing to where mesangial cells would be found. Efferent arteriole Proximal Convoluted Tubule Renal autoregulation occurs through two mechanisms: ? Myogenic response: granular cells relax or contract in response to changes in - LOW blood pressure ? granular cells relax / contract (circle one) ? afferent arteriole becomes smaller / larger (circle one) ? more / less (circle one) blood flows into glomerulus ? filtration rate restored

          14. Glomerular Filtration Rate (GFR) is the rate at which filtrate (and therefore urine) is produced. Your blood pressure varies on a daily basis for a variety of reasons, and this affects GFR: high blood pressure = high GFR (because blood is "pushing harder" on the walls of the glomerular capillaries, like a hose turned on high), low blood pressure = low GFR. In spite of these changes in blood pressure, your kidneys are able to compensate and maintain a relatively constant GFR, and thus a relatively constant production of urine. Under NORMAL conditions (blood pressure not too low or too high), GFR (and therefore urine production) is maintained by the juxtaglomerular apparatus (JGA), through a process called renal autoregulation. In the diagram below, LABEL the components of the JGA (afferent arteriole, granular cells, distal convoluted tubule (DCT), macula densa) and draw an ARROW pointing to where mesangial cells would be found. Efferent arteriole Proximal Convoluted Tubule Renal autoregulation occurs through two mechanisms: ? Myogenic response: granular cells relax or contract in response to changes in - LOW blood pressure ? granular cells relax / contract (circle one) ? afferent arteriole becomes smaller / larger (circle one) ? more / less (circle one) blood flows into glomerulus ? filtration rate restored

14. Glomerular Filtration Rate (GFR) is the rate at which filtrate (and therefore urine) is produced. Your blood pressure varies on a daily basis for a variety of reasons, and this affects GFR: high blood pressure = high GFR (because blood is "pushing harder" on the walls of the glomerular capillaries, like a hose turned on high), low blood pressure = low GFR. In spite of these changes in blood pressure, your kidneys are able to compensate and maintain a relatively constant GFR, and thus a relatively constant production of urine. Under NORMAL conditions (blood pressure not too low or too high), GFR (and therefore urine production) is maintained by the juxtaglomerular apparatus (JGA), through a process called renal autoregulation. In the diagram below, LABEL the components of the JGA (afferent arteriole, granular cells, distal convoluted tubule (DCT), macula densa) and draw an ARROW pointing to where mesangial cells would be found. Efferent arteriole Proximal Convoluted Tubule Renal autoregulation occurs through two mechanisms: ? Myogenic response: granular cells relax or contract in response to changes in - LOW blood pressure ? granular cells relax / contract (circle one) ? afferent arteriole becomes smaller / larger (circle one) ? more / less (circle one) blood flows into glomerulus ? filtration rate restored

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