Question

31. (16 pts) Fill in Boxes A-G below. For boxes E and F, I want the STRUCTURE of the corresponding molecule and you only need to fill in one box for E and one box for F. In box G, indicate what the overall effect of these transporters are. This question can easily become one where you think, "Dr. Lares said we didn't need to know..." Trust me, take a deep breath, all the information you need is in the figure if you understand how aminotranferases work and transport across the inner mitochondrial matrix works. What is the essential cofactor for the reactions indicated by the numbers 4 and 6 in the figure below? Intermembrane space (P side) Malate- OH -OOC-CH$_2$-C-COO$^- $transporter$ 2 a-ketoglutarate Matrix (N side) OH -OOC-CH$_2$-C-COO$^- B. H C. Malate Malate A. 0 3 D. E. malate dehydrogenase malate dehydrogenase E. F. Oxaloacetate Oxaloacetate F. Glutamate Glutamate 6 4 aspartate aminotransferase a-Ketoglutarate a-Ketoglutarate 0 -COO$^- -OOC-CH$_2$-CH$_2$-C-COO$^- $aspartate aminotransferase "OOC-CH$_2$-CH$_2$-C-COO$^- NH$_3$^+$ Aspartate -OOC-CH$_2$-C-COO$^- H Glutamate-aspartate transporter Figure 19-31 Lehninger Principles of Biochemistry, Sixth Edition ©2013 W. H. Freeman and Company Net effect: G. Aspartate NH$_3^+$ -OOC-CH$_2$-C-COO$^- H

          31. (16 pts) Fill in Boxes A-G below. For boxes E and F, I want the STRUCTURE of the
corresponding molecule and you only need to fill in one box for E and one box for F. In
box G, indicate what the overall effect of these transporters are. This question can
easily become one where you think, "Dr. Lares said we didn't need to know..." Trust me,
take a deep breath, all the information you need is in the figure if you understand how
aminotranferases work and transport across the inner mitochondrial matrix works.
What is the essential cofactor for the reactions indicated by the numbers 4 and 6 in the
figure below?
Intermembrane space
(P side)
Malate-
OH
-OOC-CH$_2$-C-COO$^-
$transporter$
2
a-ketoglutarate
Matrix
(N side) OH
-OOC-CH$_2$-C-COO$^-
B.
H
C.
Malate
Malate
A.
0
3
D.
E.
malate
dehydrogenase
malate
dehydrogenase
E.
F.
Oxaloacetate
Oxaloacetate
F.
Glutamate
Glutamate
6
4 aspartate
aminotransferase
a-Ketoglutarate
a-Ketoglutarate
0
-COO$^-
-OOC-CH$_2$-CH$_2$-C-COO$^-
$aspartate
aminotransferase
"OOC-CH$_2$-CH$_2$-C-COO$^-
NH$_3$^+$ Aspartate
-OOC-CH$_2$-C-COO$^-
H
Glutamate-aspartate
transporter
Figure 19-31
Lehninger Principles of Biochemistry, Sixth Edition
©2013 W. H. Freeman and Company
Net effect: G.
Aspartate
NH$_3^+$ 
-OOC-CH$_2$-C-COO$^-
H

31. (16 pts) Fill in Boxes A-G below. For boxes E and F, I want the STRUCTURE of the
corresponding molecule and you only need to fill in one box for E and one box for F. In
box G, indicate what the overall effect of these transporters are. This question can
easily become one where you think, "Dr. Lares said we didn't need to know..." Trust me,
take a deep breath, all the information you need is in the figure if you understand how
aminotranferases work and transport across the inner mitochondrial matrix works.
What is the essential cofactor for the reactions indicated by the numbers 4 and 6 in the
figure below?
Intermembrane space
(P side)
Malate-
OH
-OOC-CH2-C-COO^-transporter2
a-ketoglutarate
Matrix
(N side) OH
-OOC-CH2-C-COO^-
B.
H
C.
Malate
Malate
A.
0
3
D.
E.
malate
dehydrogenase
malate
dehydrogenase
E.
F.
Oxaloacetate
Oxaloacetate
F.
Glutamate
Glutamate
6
4 aspartate
aminotransferase
a-Ketoglutarate
a-Ketoglutarate
0
-COO^-
-OOC-CH2-CH2-C-COO^-
aspartate
aminotransferase
"OOC-CH2-CH2-C-COO^-
NH3^+Aspartate
-OOC-CH2-C-COO^-
H
Glutamate-aspartate
transporter
Figure 19-31
Lehninger Principles of Biochemistry, Sixth Edition
©2013 W. H. Freeman and Company
Net effect: G.
Aspartate
NH3^+
-OOC-CH2-C-COO^-
H

Added by John R.

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