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4. Vogelstein et al. investigated allelic deletions in colorectal tumors at three different chromosomal locations. The data is presented in Table 3. In 1988 the genes of significance located on 5q, 18q, and 17p had not yet been identified. What broad class of genes are most likely located in these regions of chromosome loss? Explain your reasoning. Table 3. Allelic Deletions in Colorectal Tumors (modified from Vogelstein et al (1988)) Chromosome | Adenoma Class I percent tumors | Adenoma Class II with deletion | Adenoma Class III (no. analyzed) | Carcinoma --- | --- | --- | --- | --- Chromosome 5q | 0 (34) | 29 (17) | 29 (14) | 36 (58) Chromosome 18q | 13 (23) | 11 (18) | 47 (17) | 73 (56) Chromosome 17p | 6 (32) | 6 (18) | 24 (17) | 75 (60) * Number of tumors that were informative for one or more of the markers on the indicated chromosome.

          4. Vogelstein et al. investigated allelic deletions in colorectal tumors at three different chromosomal locations. The data is presented in Table 3. In 1988 the genes of significance located on 5q, 18q, and 17p had not yet been identified.

What broad class of genes are most likely located in these regions of chromosome loss? Explain your reasoning.

Table 3. Allelic Deletions in Colorectal Tumors (modified from Vogelstein et al (1988))

Chromosome | Adenoma Class I percent tumors | Adenoma Class II with deletion | Adenoma Class III (no. analyzed) | Carcinoma
--- | --- | --- | --- | ---
Chromosome 5q | 0 (34) | 29 (17) | 29 (14) | 36 (58)
Chromosome 18q | 13 (23) | 11 (18) | 47 (17) | 73 (56)
Chromosome 17p | 6 (32) | 6 (18) | 24 (17) | 75 (60)

* Number of tumors that were informative for one or more of the markers on the indicated chromosome.

4. Vogelstein et al. investigated allelic deletions in colorectal tumors at three different chromosomal locations. The data is presented in Table 3. In 1988 the genes of significance located on 5q, 18q, and 17p had not yet been identified.

What broad class of genes are most likely located in these regions of chromosome loss? Explain your reasoning.

Table 3. Allelic Deletions in Colorectal Tumors (modified from Vogelstein et al (1988))

Chromosome | Adenoma Class I percent tumors | Adenoma Class II with deletion | Adenoma Class III (no. analyzed) | Carcinoma
— | — | — | — | —
Chromosome 5q | 0 (34) | 29 (17) | 29 (14) | 36 (58)
Chromosome 18q | 13 (23) | 11 (18) | 47 (17) | 73 (56)
Chromosome 17p | 6 (32) | 6 (18) | 24 (17) | 75 (60)

* Number of tumors that were informative for one or more of the markers on the indicated chromosome.

Added by Donald M.

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