Question

7. A 7-month-old boy is admitted to the hospital because of bacterial pneumonia. He had a similar occurrence last month. His temperature is \( 39.6^{\circ} \mathrm{C}\left(103.3^{\circ} \mathrm{F}\right) \), and respirations are \( 48 / \mathrm{min} \). Physical examination shows decreased breath sounds and crackles at the base of the right lung. Laboratory studies indicate poor antibody responses against the childhood vaccines given thus far, and that HLA-DR molecules are not expressed on his peripheral blood lymphocytes. A diagnosis of bare lymphocyte syndrome is made. Which of the following immune response mechanisms is most likely impaired in this patient? A) Activation of the lectin pathway of complement B) Antigen presentation to CD4+ T lymphocytes C) Generation of class I MHC-peptide complexes D) Macrophage phagocytosis E) Processing of endogenous antigens

          7. A 7-month-old boy is admitted to the hospital because of bacterial pneumonia. He had a similar occurrence last month. His temperature is \( 39.6^{\circ} \mathrm{C}\left(103.3^{\circ} \mathrm{F}\right) \), and respirations are \( 48 / \mathrm{min} \). Physical examination shows decreased breath sounds and crackles at the base of the right lung. Laboratory studies indicate poor antibody responses against the childhood vaccines given thus far, and that HLA-DR molecules are not expressed on his peripheral blood lymphocytes. A diagnosis of bare lymphocyte syndrome is made. Which of the following immune response mechanisms is most likely impaired in this patient?
A) Activation of the lectin pathway of complement
B) Antigen presentation to CD4+ T lymphocytes
C) Generation of class I MHC-peptide complexes
D) Macrophage phagocytosis
E) Processing of endogenous antigens

7. A 7-month-old boy is admitted to the hospital because of bacterial pneumonia. He had a similar occurrence last month. His temperature is 39.6^∘C(103.3^∘F), and respirations are 48 / min. Physical examination shows decreased breath sounds and crackles at the base of the right lung. Laboratory studies indicate poor antibody responses against the childhood vaccines given thus far, and that HLA-DR molecules are not expressed on his peripheral blood lymphocytes. A diagnosis of bare lymphocyte syndrome is made. Which of the following immune response mechanisms is most likely impaired in this patient?
A) Activation of the lectin pathway of complement
B) Antigen presentation to CD4+ T lymphocytes
C) Generation of class I MHC-peptide complexes
D) Macrophage phagocytosis
E) Processing of endogenous antigens

Added by William C.

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